Сustom chemistry services

Scale up Method development and chemical synthesis

 Development and validation of new methods for the synthesis of compounds (series from 100 mg to 100 g):

• Synthesis of individual innovative and well-known small molecules, active substances and impurities with a purity of up to 90-99%
• Synthesis of libraries of chemical compounds for in vitro research (10-100 compounds per scaffold)

Scaling and optimization of synthesis methods and technologies (batch up to 1-100 kg):

• Scaling and development of laboratory regulations for the production of substances obtained by chemical synthesis methods
• Chemical reactions with a large volume of reagents (up to 30 liters), using both laboratory and pilot-industrial systems for synthesis
• Purification of large reaction volumes by laboratory and high-tech methods — distillation at low pressure, chromatography, recrystallization, etc.
• Ability to develop synthesis methods with subsequent staging of technology and validation of analytical methods and development of GMP production technology

Development and validation of analytical quality control procedures:

• Analysis of synthesized compounds by HPLC, LCMS, NMR
• High performance automated analysis and cleaning

Chemical analytics capabilities:

HPLC LCMS                                                                                    NMR

UPLS/MS Shimadzu 2020                                                     Bruker DPX-300

PE Sciex API 150EX LC-MS/MS                                         Bruker DPX-400

LCMS system Shimadzu 2010 EV

Preparative LCMS/PREP system Shimadzu 2020 

 Methods and technologies

• Heterocyclic chemistry
• Organometallic chemistry
• Cascade assembly of structures
• Microwave synthesis
• Synthesis, separation of stereoisomers and enantiomers
• High pressure reactions
• Parallel and asymmetric synthesis and others